|Definition||Syphilis is a sexually transmitted infection caused by a spiral-shaped bacterium – pale Treponema (Treponema pallidum).|
|History||The first syphilis epidemic in Europe was characterized by a malignant course of the disease with general symptoms, pustular and ulcerative manifestations and a relatively rapid development of visceral and neurological lesions, often leading to death. In 1498, Francesco Lopez de Villalobos, and then in 1530, Girolamo Fracastoro described in detail hard chancre, lymphadenitis, skin lesions, and mucous membranes of the secondary syphilis. The first accurate, strictly scientific description of the course of syphilis was made as a result of the experience of self-infection by the English surgeon John Hunter in 18th century.|
|Symptoms||Some infected people may not have symptoms of syphilis for years, but this does not reduce the risk of later serious complications if they have not received treatment. The primary stage of syphilis is usually manifested by one or more sores or so-called chancres. The period from infection to the onset of clinical symptoms is from 10 to 90 days (average 21 days). Usually, the chancre is small, round, firm, red in color, and painless. Chancre appears in the place where the causative agent of syphilis enters the human body. Secondary syphilis is manifested mainly by a rash on the body or on visible mucous membranes.|
|Causes||The spirochete Treponema pallidum is the causative agent of syphilis, which is transferred from body to body upon contact with secretions and mucous membranes of a sick person.|
|Virology||The pathogen is transmitted through direct sexual contact (vaginal, oral or anal sex) from infected partners. The bacterium penetrates through mucous membranes or damaged skin upon contact with syphilitic sores. Ulcers caused by the disease can be found on the external genitalia, in the vagina, on the anus and in the rectum.|
|Prevention||The best way to prevent sexually transmitted infections (including syphilis) is through long-term sexual contact with one healthy sexual partner.|
|Diagnostic Method||The diagnosis of primary syphilis is made if a chancre is found on the genitals, and a thorough questioning of the patient about his sexual contacts is also carried out. However, often patients do not have any manifestations of the disease. Diagnosis at an early stage can be carried out using the dark-field microscopy, in which case the material is taken from the chancres and pale Treponema is found.|
|Treatment||A course of penicillin is usually used, administered intramuscularly in injections. Patients who are allergic to penicillin are treated with other drugs.|
|Duration||Treatment lasts from 2 months to several years. Only after control examinations with negative syphilis results, carried out at certain intervals, the patient can return to a full life.|
|Prognosis||Syphilis is easily curable in the early stages. Since there is an effective treatment for early syphilis, it is very important to test for syphilis in people who have frequent promiscuity.|
|Complications||Without treatment, infected individuals remain carriers of the disease, even if they do not have symptoms of the disease. At a later stage, internal organs are affected: the brain, nerves, eyes, heart, blood vessels, liver, bones and joints. Complications include difficulty in coordinating movements, paralysis, lack of sensation, gradual blindness and dementia, and are most often not curable.|
|Frequency in Population||According to WHO, globally, there were an estimated 7 million new syphilis infections in 2020.|
|Deaths||During 1968-2015, there were 6,498 deaths attributed to syphilis; 4,149 males and 2,349 females. Nowadays, the number of deaths from syphilis has decreased due to the introduction of effective treatment.|
|Society||Syphilis bears a serious stigma in the society, being associated with drug use, sex work, and promiscuity. People who seek treatment from syphilis prefer to attend anonymous consultations.|
📝 Syphilis Research Papers Examples
- Epidemiology: AIDS, Syphilis, Tuberculosis in Miami-DadeThis analysis focuses on such infectious diseases as AIDS, syphilis, and tuberculosis, which are rather frequent among the citizens of Miami-Dade County.
- Epidemiology: HIV, Syphilis, Gonorrhea in Miami-DadeThe central objective of the intervention and its goals should be aligned with Healthy People 2020 that considers HIV and STD critical health concerns.
- Epidemiology: HIV&AIDS, Syphilis, Influenza A in MiamiThe overall sexually transmitted disease rates in Miami-Dade are below the Florida average, yet the situation is different with syphilis rates.
🏆 Best Syphilis Essay Titles
- Spatial and Temporal Epidemiology of Infectious Syphilis in Victoria, Australia, 2015–2018
- Congenital Syphilis Prevention: Strategies, Evidence, and Future Directions
- Treatment of Syphilis With Doxycycline in a Pregnant Woman Unable to Be Desensitized to Penicillin
- Ugly History: The Us Syphilis Experiment
- The Evidence for the Sexual Transmission of Syphilis From Asymptomatic Persons
- Partner Notification Among Persons With Early Syphilis in Shenzhen, China, 2011–2017
- Syphilis Elimination: Lessons Learned Again
- Predicting Emergence of Primary and Secondary Syphilis Among Women of Reproductive Age in Us Counties
- Primary Syphilis of the Neck Mimicking Pyodermatitis
- Syphilis: Background, Pathophysiology, Etiology
- The Estimated Lifetime Medical Cost of Syphilis in the United States
- Age-Old Syphilis and Its Modern Day Rampage
- Factors Associated With Syphilis Testing and a History of Syphilis Infection Among a Sample of Transgender Women in Jamaica
- The Natural History of Syphilis: Implications for the Transmission Dynamics and Control of Infection
- Syphilis Vaccine Development: Requirements, Challenges, and Opportunities
- Costs of Identifying Cases of Syphilis Using Rapid Syphilis Tests in Multiple Nonclinical Settings in the United States
- Detection of Treponema Pallidum Dna in Oropharyngeal Swabs and Whole Blood for Syphilis Diagnosis
- Syphilis and the Columbian Theory
- Gonorrhea, Gonorrhea and Syphilis Testing
- Revisiting the Great Imitator: The Origin and History of Syphilis
- Provider Adherence to Syphilis Testing Guidelines Among Stillbirth Cases
- Syphilis Ascendant: A Brief History and Modern Trends
- The History of Congenital Syphilis Behind “The Inheritance” by Edvard Munch
- Syphilis – Its Early History and Treatment Until Penicillin
- Estimates of the Prevalence and Incidence of Syphilis in the United States, 2018
- Rising Syphilis Rates During the COVID-19 Pandemic
- Syphilis: Symptoms, Treatment, Is It Curable, and Diagnosis
- Syphilis Treatment & Management: Approach Considerations
- Risk Factors for Syphilis at a Large Urban Emergency Department
- Preventing Congenital Syphilis—Opportunities Identified by Congenital Syphilis
- Syphilis Control in the Postelimination Era: Implications of a New Syphilis Control Initiative for Sexually Transmitted Disease
- Ocular Syphilis and Human Immunodeficiency Virus Coinfection Among Syphilis Patients in North Carolina, 2014–2016
- Ethical and Unethical Conduct of Syphilis
- Clinical and Ophthalmological Characteristics of Ocular Syphilis in a Retrospective Tertiary Hospital Cohort
- Ending the HIV Epidemic: Contributions Resulting From Syphilis Partner Services
- Lifetime Syphilis Prevalence and Associated Risk Factors Among Female Prisoners in Brazil
- Tuskegee Experiment: The Infamous Syphilis Study
- The Controversy Surrounding the Syphilis Experiment
- Coinfection With Chlamydial and Gonorrheal Infection Among Us Adults With Early Syphilis
- The Origin, Etiology, and Treatment of Syphilis
❓ Syphilis Research Questions
- How Common Is Syphilis?
- How Is Syphilis Spread?
- Where Did Syphilis Originally Come From?
- How Can Syphilis Be Prevented?
- What Are the Symptoms of Syphilis?
- How Does Having Syphilis Affect a Pregnant Woman and Her Baby?
- How Is Syphilis Diagnosed?
- What Is the Treatment for Syphilis?
- What Are the Symptoms & Signs of Syphilis?
- How Syphilis Affected African Americans?
- What Happens if Syphilis Is Left Untreated?
- Can You Get Syphilis Non-Sexually?
- Is Syphilis an STD or STI?
- Is Syphilis 100% Curable?
- What’s Involved in Syphilis Testing?
- How Can One Reduce Risk of Getting Syphilis?
- Can One Get Syphilis Again, After Receiving Treatment?
- Who First Discovered Syphilis?
- When Was Syphilis a Pandemic?
- How Epidemic Context Influences Syphilis Screening Impact?