A Medication Class That Is Used to Treat Seizure Disorder
The contemporary treatment of seizures began in 1850 when bromides were introduced after discovering that epilepsy was caused by intense sexual urge. However, phenobarbital (PHB) was discovered in 1910, and the drug was used to induce sleep in the patients (Gschwind & Seeck, 2016). The drug has, however, gone developed and used for several years as antiseizure. Over the years, drugs used for seizure treatment have undergone classification. This implies that the drugs are grouped based on their action and function. This has moonily been performed to ensure that drug safety is enhanced, and the goal of the drug is achieved. Therefore, the drugs used to treat seizures belong to anticonvulsant drugs.
Three Medications Within the Class
Over the years, anticonvulsant drugs have increased, enhancing medication choices for patients and their doctors. However, despite the variety of drugs, the drugs are used on a patient depending on the type of seizures experienced. According to Klinger and Mittal (2018), the drugs can not cure the disease but act as a control mechanism that can be used to control the disease; hence, the patients are required to continuously talkie their medications. The three main medications within the class include Brivaracetam, also referred to as Briviact, Cannabidiol popularly known as Epidiolex, and Carbamazepine which is regarded as Carbatrol or Tegretol.
Each Drugs’ Mechanism
|Brivaracetam||modulates synaptic GABA release||– for partial seizures with complex symptomatology (psychomotor, temporal lobe) (Khaleghi & Nemec, 2017).||Completely absorbed after oral administration||Evenly distributed in most body tissues||metabolized by hydrolysis, through amidase enzymes|
|Cannabidiol||acts on cannabinoid (CB) receptors of the endocannabinoid system||active at Cannabinoid-1 (CB1R) and Cannabinoid-2 (CB2R) receptors||Slowly absorbed after diverse routes of administration||analyte distribution throughout the body||metabolism by the liver and extra-hepatic tissues|
|Carbamazepine||A sodium channel blocker binds preferentially to voltage-gated sodium channels in their inactive conformation, preventing the repetitive and sustained firing of an action potential.||It inhibits all sodium channels||Slowly Fairly completed after oral administration||Distributed in most body tissues||Largely metabolized in the liver|
Gschwind, M. A., & Seeck, M. (2016). Modern management of seizures and epilepsy. Swiss medical weekly, 146, w14310.
Khaleghi, F., & Nemec, E. C. (2017). Brivaracetam (privacy): a novel adjunctive therapy for partial-onset seizures. Pharmacy and Therapeutics, 42(2), 92.
Klinger, N., & Mittal, S. (2018). Deep brain stimulation for seizure control in drug-resistant epilepsy. Neurosurgical Focus, 45(2), E4.